Sherbrooke, Nova Scotia (population ~400) is a Canadian rural community in Guysborough County, Nova Scotia.
Sherbrooke is nestled between Sherbrooke Lake and St. Mary's River. The river was named for Fort Saint Marie, a French-built fort which was later taken over and destroyed by the British, and is renowned for its angling and its run of wild Atlantic salmon.
It is famous regionally for being the home of Sherbrooke Village, the largest Nova Scotia Museum site in the province.
The community takes its name from Sir John Coape Sherbrooke, a colonial era Lieutenant-Governor of Nova Scotia.
Sherbrooke is the administrative seat for the Municipality of the District of St. Mary's. The local high school Saint Mary's Academy (formerly Saint Mary's Rural High) despite it's small size were the provincial volleyball champions in 1977.
Economically, Sherbrooke and its surrounding area depend on natural resource extraction, such as lumber and fishing.